Stage T1 bladder cancer: historic background and latest tracks for its demystification
نویسندگان
چکیده
منابع مشابه
Stage T1 Bladder Cancer – Aspects of Diagnosis and Treatment
Bladder cancer is the most common malignant tumour in the urinary tract. Approximately 75% of the cases are non-muscle-invasive cancers that can be treated with transurethral resection of the bladder (TURB). One fourth of the patients present with muscle-invasive tumours and require radical cystectomy, occasionally in combination with chemotherapy. In stage T1 bladder cancer, the tumour is not ...
متن کاملp53 status correlates with the risk of progression in stage T1 bladder cancer: a meta-analysis
BACKGROUND Published studies have yielded inconsistent results on the relationship between p53 status and the progression of stage T1 non-muscle invasive bladder cancer (NMIBC). Therefore, we performed a meta-analysis to evaluate the prognostic value of p53 in T1 NMIBC. METHODS We systematically searched for relevant literatures in MEDLINE, EMBASE, and Web of Science. Data were pooled togethe...
متن کاملImmunohistochemical Evaluation of Cell Cycle Regulators: Impact on Predicting Prognosis in Stage T1 Urinary Bladder Cancer
Background and Objective. The cell cycle is regulated by proteins at different checkpoints, and dysregulation of this cycle plays a role in carcinogenesis. Matrix metalloproteinases (MMPs) are enzymes that degrade collagen and promote tumour infiltration. The aim of this study was to evaluate the expression of various cell cycle regulators and MMPs and to correlate such expression with progress...
متن کاملp53 and RB expression predict progression in T1 bladder cancer.
The optimal clinical management of minimally invasive (stage T1) bladder cancer is controversial. T1 bladder cancers share characteristics of both noninvasive (Ta) papillary cancer and high stage, muscle-invasive bladder cancers. Patients with T1 bladder cancer have a higher risk of cancer progression and death than do patients with Ta bladder cancer. However, this risk is much lower than that ...
متن کاملTumor budding, a novel prognostic indicator for predicting stage progression in T1 bladder cancers
Tumor budding has been defined as an isolated single cancer cell or a cluster composed of fewer than five cancer cells scattered in the stroma. It is a strong predictor for lymph node metastasis in T1 colorectal cancer. We introduced this concept to T1 non-muscle invasive bladder cancer and evaluated whether tumor budding could have a prognostic impact on the clinical outcome. We identified 121...
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ژورنال
عنوان ژورنال: Translational Andrology and Urology
سال: 2018
ISSN: 2223-4683,2223-4691
DOI: 10.21037/tau.2018.06.13